A summary of Zywiec et al.’s landmark multi-author review in the Journal of American Physicians and Surgeons (Fall 2025) — covering gain-of-function origins, systemic adverse events, and the ethical reckoning ahead.
Why This Paper Matters
In Fall 2025, a multi-disciplinary team of eleven physicians, epidemiologists, and independent researchers published what Zywiec et al. describe as a “non-exhaustive conclusion” on the harms and damages associated with COVID-19 modified mRNA biologics and vaccines. The paper, published in the Journal of American Physicians and Surgeons, synthesizes evidence from large-scale epidemiological studies, military health records, autopsy analyses, clinical cohort data, and peer-reviewed case reports.
The scope is striking. The authors argue that the evidence now points to systemic harm across nearly every major organ system — from cardiovascular catastrophes and autoimmune cascades to reproductive complications and aggressive cancers — and that the pattern cannot be dismissed as coincidental.
For families and high-net-worth individuals who make health decisions based on data rather than headlines, this paper represents one of the most comprehensive consolidations of the clinical evidence to date.
Origins: Gain-of-Function and Engineered Features
The paper’s authors contend that SARS-CoV-2 displays multiple genomic features indicative of laboratory manipulation. They point to the furin cleavage site (FCS) — a rare insertion in coronaviruses that enhances infectivity and is absent in SARS-like viruses found in nature — along with HIV-like inserts, a superantigen motif, and unusual viral durability.
Zywiec et al. note that the DEFUSE proposal, submitted by EcoHealth Alliance to DARPA in 2018, described the intentional creation of chimeric coronaviruses with these exact features. The authors argue that senior NATO military scientists rated SARS-CoV-2 as the fourth most attractive pathogen among 34 known or potential bioweapons, and that the virus’s engineered features match the goals of four of seven categories of gain-of-function experiments.
The virus (and vaccine) contains evidence of manipulation, and those specific manipulations match the goals of four of seven categories of GOF experiments. — Zywiec et al., JAPS Fall 2025
Suppression of Information and Early Vaccine Development
The authors document a timeline of information suppression that they argue delayed public awareness and pandemic mitigation. They note that a vaccine prototype was designed by Fauci’s Vaccine Research Center and Moderna by January 13, 2020 — before human-to-human transmission was officially confirmed.
Zywiec et al. describe a February 1, 2020 teleconference convened to suppress concerns about HIV-like inserts and the furin cleavage site, followed by the coordinated publication of the “proximal origin” paper to discredit lab-origin theories. The authors argue that proven or promising treatments such as hydroxychloroquine and vitamin D were suppressed in favor of a vaccine-first strategy.
Military Health Records: The DMED Signal
One of the paper’s most compelling data sources is the Defense Medical Epidemiology Database (DMED), part of the U.S. military’s Defense Medical Surveillance System. The authors present data analyzed by Lt. Edward Macie, USN, through April 2025, showing persistent elevations against the 2016–2020 baseline.
The authors report that approximately 95,000 service members separated, retired early, or were medically discharged during the COVID-19 vaccine mandate period, raising concerns about military medical readiness.
Autoimmune and Immune Dysfunction
The paper presents data from multiple clinical studies documenting widespread immune system disruption following mRNA vaccination. Rodríguez et al.’s systematic review of 928 post-vaccination autoimmune cases found that 81.5% were new-onset, not pre-existing conditions, with 4.7% of new cases resulting in death.
Data from a Florida cohort of 817 vaccine-injured retirees showed autoimmune markers in 74.8% of patients, T-cell deficiencies in 32%, and humoral dysfunction in nearly 22%. Viral reactivation — including Epstein-Barr virus, herpes simplex, HHV-6, and cytomegalovirus — was documented in greater than 90% of those assessed.
Patterson et al. identified persistent S1 spike protein in circulating monocytes of vaccinated individuals with long COVID, suggesting prolonged antigen exposure as a driver of post-vaccination immunological dysfunction.
Cardiovascular Adverse Events: Data Across 184 Million People
The paper consolidates four landmark studies encompassing a combined 184 million individuals, reporting consistent and significant increases in serious heart conditions following mRNA vaccination:
Source studies: Faksova et al. (myocarditis, n=99M); Raheleh et al. (heart attack, stroke, arrhythmia, n=85M).
Reproductive and Pregnancy Risks
The reproductive findings represent some of the most concerning data in the paper. Pfizer’s own post-market surveillance report, completed in February 2021, documented 42,086 adverse events including 1,223 deaths within 10 weeks of rollout.
The authors highlight a re-analysis of the Shimabukuro et al. study in the New England Journal of Medicine, arguing that when corrected for trimester timing (the majority of women were vaccinated in the third trimester, outside the miscarriage window), the miscarriage rate adjusts to approximately 82% — comparable to the abortion pill RU-486.
Pfizer’s Phase 2/3 clinical trial in 324 pregnant women showed a 310% increase in congenital anomalies with developmental delays at six months in the vaccinated group. Studies by Lin et al. confirmed transplacental mRNA transfer into fetal blood, while Hanna et al. detected intact mRNA in breast milk — confirming exposure pathways to the unborn and nursing infants.
Oncology: The Aggressive Cancer Signal
Since 2021, the authors document a pattern observed by oncologists worldwide: more cancers in younger patients, faster progression, late-stage presentation at diagnosis, and relapses in patients previously in remission. The paper identifies four proposed biological mechanisms:
Weakened immune surveillance. Vaccine-induced lymphopenia reduces the CD4+/CD8+ T-cell populations responsible for detecting and destroying cancer cells.
IgG4 tolerance switch. Repeated mRNA boosters elevate IgG4 antibodies that may signal the immune system to tolerate rather than fight tumor cells.
DNA contamination. Independent labs identified plasmid DNA including the SV40 sequence (historically linked to cancer) in Pfizer’s vaccine.
Chronic inflammation. Persistent spike protein exposure creates immunological exhaustion and pro-tumorigenic conditions.
DMED data shows digestive organ cancer increasing from 15.8% above baseline in 2021 to 46.3% in 2023. Brain cancer elevated 40.1% above baseline in 2023. The authors argue these trends are consistent across U.S., UK, and Japanese epidemiological data.
Aberrant Protein Production: The N1-Methylpseudouridine Problem
One of the paper’s most technically significant sections addresses the incorporation of N1-methylpseudouridine (m1Ψ) into modified mRNA vaccines. The authors argue that this modification, designed to reduce immunogenicity, alters base-pairing dynamics during translation, potentially causing ribosomal frameshifts that produce unintended proteins.
Zywiec et al. calculate that with 728 m1Ψ substitutions in the BNT162b2 vaccine, each capable of independently causing a frameshift, the theoretical number of unique protein sequences vastly exceeds the number of atoms in the observable universe. While cellular quality control mechanisms mitigate this, the authors argue the potential for significant aberrant protein production persists.
These aberrant proteins may trigger autoimmune responses through molecular mimicry, contribute to protein aggregation disorders, overwhelm cellular degradation pathways, or in rare cases produce functional but unintended proteins with epigenetic or tumorigenic effects.
The Future of mRNA Biologics: 150–200 Programs in Development
The paper’s final scientific section addresses the expanding mRNA pipeline. The authors note that as of 2025, more than 1,160 clinical trials have been initiated since 2019 using mRNA, self-amplifying RNA (saRNA), and circular RNA (circRNA) platforms, targeting cancer, infectious diseases, and rare genetic disorders.
The authors raise a fundamental concern: there are no mechanisms to regulate protein dose, duration, or cessation once mRNA biologics are administered. They note that S1 spike protein has been detected more than 700 days post-COVID vaccination, and that self-replicating saRNA and the stability of circRNA exacerbate these risks.
This trajectory evokes historical medical oversteps, such as the widespread use of lobotomies in the mid-20th century, where enthusiasm for a novel intervention outpaced understanding of its devastating consequences. — Zywiec et al., JAPS Fall 2025
Mandates, Ethics, and the Erosion of Public Trust
The paper’s biopsychosocial section documents the collateral damage of vaccine mandates: ethical violations of informed consent principles enshrined in the Nuremberg Code and Helsinki Declaration, social fracture between vaccinated and unvaccinated communities, and a measurable erosion of public health trust that reduced uptake of routine vaccines.
A Seoul-based molecular psychiatry study linked COVID-19 vaccination to increased risks of depression (HR 1.68), anxiety disorders (HR 1.44), and sleep disorders (HR 1.93). A 2024 PNAS study found that U.S. state mandates failed to increase COVID-19 vaccination rates and actually reduced booster and flu vaccine uptake compared to states with mandate bans.
What the Authors Call For
Zywiec et al. conclude with three demands:
1. Immediately halt all mRNA vaccine and biologic programs pending comprehensive, independent safety reviews.
2. Launch full investigations into the origins of SARS-CoV-2 and the gain-of-function research behind it.
3. Restore ethical medicine: rebuild informed consent, remove liability shields, and return to trust-based public health.
The surge in autoimmune diseases, heart damage, pregnancy losses, and aggressive cancers demands answers. The evidence points to systemic harm — and those responsible must be held accountable. — Zywiec et al., JAPS Fall 2025
Key Takeaways
1. Multi-system harm is now documented across 184 million people in cardiovascular studies alone. Four landmark studies report consistent, significant increases in myocarditis, heart attack, stroke, and arrhythmia.
2. Military health data (DMED) provides a controlled population baseline. Persistent elevations in myocarditis, brain cancer (+40.1%), and digestive cancers (+46.3%) through 2023–2024.
3. Autoimmune disease, immune dysfunction, and viral reactivation are widespread. Clinical cohort data shows 81.5% new-onset autoimmune disease and >90% viral reactivation in assessed patients.
4. Reproductive risks are severe and documented. Transplacental mRNA transfer, mRNA in breast milk, and a re-analyzed miscarriage rate of 82% demand urgent attention.
5. 150–200 mRNA programs are in development globally. Without an “off switch” for protein expression and with spike protein detected 700+ days post-vaccination, the authors argue the risk profile of next-generation mRNA biologics requires fundamental reassessment.
6. Informed consent and independent safety review are non-negotiable. The authors call for an immediate halt to mRNA programs pending comprehensive investigation.